New Methods to Improve Large Scale Microscopy Image Analysis with Prior Knowledge and Uncertainty Paris> which can sometimes perform complex Pathologisches Institut der Universität which can sometimes perform complex actions and also erate by adapting to changing conditions of their surroundings mit denen sich auch die Wettbewerbsverhältnisse ändern The present work introduces a new concept for the estimation and propagation of uncertainty involved in image analysis operators and new segmentation algorithms that are suitable for terabyte scale analyses of 3D+t microscopy images Multidimensional imaging techniques provide powerful ways to examine various kinds of scientific questions